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Hydroxypropyl Gamma Cyclodextrin (HP-γ-CD)
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seat: Shandong
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Last update: 2024-03-22 02:02
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Product details



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Name

Hydroxypropyl gamma cyclodextrin (HP-γ-CD)

CAS No.

128446-34-4

Molecular Formula

C48H80-nO40.(C3H7O)n

Molecular Weight

1297.2+n.(58.1)

Appearance

White powder, insipid, innocent

Assay

≥98％

Classification

Pharmaceutical Grade

Quality standard

Enterprise Standard

DMF No.

037142


 



Molecular structuer:





 






Product Introduction




 



Hydroxypropyl-gamma-cyclodextrin (HPγCD) is a modified cyclodextrin derivative. It is obtained by introducing hydroxypropyl groups onto the gamma-cyclodextrin molecule. Structurally, HPγCD is similar to hydroxypropyl-beta-cyclodextrin(HPβCD) and hydroxypropyl-alpha-cyclodextrin (HPαCD), but typically contains eight glucose units in its cyclic structure.And it can interact with larger molecules. It is a very useful chemical for Supramolecular chemistry.



 






Factory introduction




 



Zhiyuan Biotech has passed ISO9001 quality system certification, ISO14001:2015 environmental management system certification, and ISO45001:2018 occupational health and safety management system certification.



The company has established a domestically advanced GMP standard clean production system for pharmaceutical excipients and a complete development and quality inspection center. Cyclodextrin reagents are domestically proprietary and are exclusively supplied to university laboratories and scientific research institutions at home and abroad.



Hydroxypropyl gamma cyclodextrin manufacturer-Shandong Binzhou Zhiyuan Biotechnology Co., Ltd which has completed registration with FDA, and the registration information is as follows:



Company name: Shandong Binzhou Zhiyuan Biotechnology Co., Ltd



FDA ESTABLISHMENT IDENTIFIER (FEI No.)：3011680310



ESTABLISHMENT ADDRESS: Boxing Economic Development Zone,, Binzhou, Shandong 256500, China (CHN)



DUNS: 548171477




















Product Specification




 






































































Test Standard

Enterprise standard

ITEMS

SPECIFICATION

Appearance

White powder, insipid, innocent

Assay

≥98％

Absorbance

The absorbance at 230~350nm should not exceed 0.50, while at 350~660nm should not exceed 0.5

PH

6.0 ~ 9.0

Loss on Drying

≤10.0％

Gamma cyclodextrin

≤1.5％

Propylene glycol

≤0.5％

Residue on Ignition

≤0.2％

Heavy Metal

≤10ppm

Molar Substitution

0.5-0.7

Microbiology

Aerobic microorganism

≤1000CFU/g

Moulds & yeasts

≤100CFU/g

Escherichia Coli

Absence


 






Product advantages




 



1. The quality is stable and has been audited by customers many times and received high praise.



2. Complete China CDE filing and U.S. FDA filing.



3. Binzhou Zhiyuan Biotechnology obtained ISO 9001, ISO14001, and ISO45001 certifications



4. Strong supply capacity: 100 tons/year



5. Provide technical support.



 





















 



 






Features




 



Hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) exhibits increased water solubility compared to its parent compound, gamma-cyclodextrin. At 25°C, HP-γ-CD can reach a solubility of up to 80g/100ml in water. This enhanced solubility is attributed to the hydroxypropyl groups attached to the cyclodextrin molecule, which increase its hydrophilicity and improve its interaction with water molecules.



Furthermore, it's important to note that HP-γ-CD is not a single pure compound but rather a mixture of multiple substituted compounds. The introduction of hydroxypropyl groups onto the gamma-cyclodextrin structure leads to the coexistence of various substitution patterns within the HP-γ-CD molecule. This structural diversity contributes to the versatility of HP-γ-CD and its ability to accommodate a wide range of guest molecules.



Due to the increased complexity and structural variations, HP-γ-CD exhibits unique properties compared to pure gamma-cyclodextrin. Specifically, the presence of multiple substitution sites and patterns makes it more challenging for HP-γ-CD to form inclusion crystallization with guest molecules. Inclusion crystallization refers to the formation of well-defined crystalline inclusion complexes where guest molecules are encapsulated within the cyclodextrin cavity. The reduced propensity for inclusion crystallization in HP-γ-CD can be attributed to the steric hindrance caused by the hydroxypropyl groups, hindering the perfect alignment required for crystallization.



Overall, HP-γ-CD demonstrates higher water solubility and stronger anti-crystallization ability compared to gamma-cyclodextrin. These characteristics make HP-γ-CD a valuable tool in various applications, such as solubilization, stabilization, taste masking, and controlled drug release, where improved water solubility and reduced crystallization tendencies are beneficial.



 






Application




 






1



Pharmaceutical formulations: HP-γ-CD is commonly used in the preparation of oral medications, injectables, eye drops, transdermal patches, and other formulations to enhance drug solubility, stability, and bioavailability.






2



Solubilizer: Due to its ability to enhance the solubility of poorly water-soluble drugs, HP-γ-CD is used to improve the dissolution rate of drugs, making them more readily absorbed and utilized in the body.






3



Taste masking: Certain drugs have a bitter taste or unpleasant odor, which can affect patient acceptance, especially in children and the elderly. HP-γ-CD can mask the bitter taste and unpleasant odor of drugs, improving the palatability and acceptance of oral liquid formulations.






4



Drug stabilizer: HP-γ-CD can enhance the stability of drugs, particularly those prone to degradation or oxidation. By encapsulating drug molecules within its cavity, HP-γ-CD can protect drugs from external factors such as light, heat, and humidity, extending the shelf life of drug formulations.






5



Controlled release systems: HP-γ-CD can be used to control the release rate of drugs from formulations. By modulating the structure and properties of inclusion complexes, it can regulate the release kinetics of drugs, enabling sustained or targeted drug delivery.






6



Cosmetics: HP-γ-CD is increasingly used in the cosmetics industry. It can enhance the stability and solubility of active ingredients in cosmetics, improve their absorption and utilization, and can also mask unpleasant odors in certain cosmetic products.






7



Food industry: HP-γ-CD is also used as an additive in the food industry to improve the stability, solubility, and sensory properties of active ingredients in food products.







 






Packing & Storage




 



● Internal packing: packed PE bag, then put into aluminum foil bag



● Storage: Preserve well-closed containers protect from moisture.



● Label: according to customers' request.



● Outer packing: packed in drum.



● Packing:100g/bag, 1kg/bag, 2kg/bag, 10kg/bag/drum, 20kg/bag/drum



 




















Delivery




 







1





Stock:



Goods in stock







2





Delivery:



Delivery goods within 1-3 workdays.







3





Loading location:



factory of Binzhou Zhiyuan(China)







4





Shipping:



FOB, CIF, CFR, DDU.....



 







 



 






Certificate




 





 



 






FAQ




 







Q: Do you accept sample order?




A: We accept sample orders.MOQ: 0.1kg.





Q: How to confirm the product quality before placing orders?




A: It is recommended to test the quality of the samples before placing an order, as we can ensure that the quality of the order is consistent with the quality of the samples.





Q: Do you supply product report?




A: Yes. We'll give you product analysis report before shipping.





Q: Is there a discount?




A: Different quantity has different discount.





 






Application case




 



In olopatadine hydrochloride Ophthalmic Solution, Hydroxypropyl gamma cyclodextrin (HP-γ-CD) is the best forming agent.



 



Olopatadine eye drops are solution agents, which are used to treat signs and symptoms of allergic Conjunctivitis. It can be used for the treatment of bacterial Conjunctivitis, Keratitis, dacryocystitis, postoperative infection and other external eye infections.



 



Hydroxypropyl gamma Cyclodextrin can significantly enhance the solubility of Olopatadine in aqueous solution, reduce the bitterness of Olopatadine, and greatly improve the stability of olotadine. Because of the inclusion effect of hydroxypropyl gamma Cyclodextrin on Olopatadine, Olopatadine can be slowly released, which can increase the administration time in the actual administration process.

http://www.icyclodextrin.com/

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